Accelerated aging of the putamen in men but not in women

作者：Nunnemann Sabine; Wohschlaeger Afra M; Ilg Ruediger; Gaser Christian; Etgen Thorleif; Conrad Bastian; Zimmer Claus; Muehlau Mark

来源：Neurobiology of Aging, 2009, 30(1): 147-151.

DOI：10.1016/j.neurobiolaging.2007.05.016

• Putamen
• Gender
• Aging
• Voxel-based morphometry

Age-related strucutral brain changes have been demonstrated repeatedly hut data on the effect of gender on age-related structural brain changes are conflicting. Using high-resolution T1-weighted magnetic resonance imaging and voxel-based morphometry, we examined a population of 133 healthy adults (women, 73; men, 60; age range, 29-80 years) focusing on differential aging between men and women (i.e., interaction of age and gender). Compared to women, men showed accelerated age-related gray matter (GM) loss in the posterior putamen. Our data may constitute the structural substrate for age-related differences in motor function however men and women such as the higher incidence and earlier onset of Parkinson's disease in men.

• 出版日期2009-1