Subpathway Strategy used to Extract Significant Subpathways Competitively Regulated by IncRNAs in Atopic Dermatitis Treated by Cyclosporine A Based on IncRNA-mRNA Expression Data and Pathway Topologies

作者：Su, Chun-Ying; Li, Yun-Xia; Zhao, Yan-Zhong^*

来源：International Journal of Human Genetics, 2018, 18(2): 162-171.

• Atopic Dermatitis
• IncRNA Competitively Regulated Signal Pathways
• Long Noncoding RNAs
• Pearson Correlation Coefficien
• Subpathway

The aim of this study was to extract significant subpathways to further investigate the molecular mechanism of cyclosporine A (CsA) in patients with atopic dermatitis (AD) using subpathway strategy. Candidate IncRNA-mRNA interactions were reweighted using Pearson Correlation Coefficient (PCC). Condition-specific IncRNA competitively regulated signal pathways (LRSP) were established, and then IncRNA-regulated subpathways were dissected. Subsequently, the significance of candidate subpathways was assessed to further identify the significant subpathways. To further detect key AD-relevant IncRNAs. degree analysis was conducted for all nodes of the LRSP. Overall 61 significant IncRNAs competitively regulating subpathways involved in 41 complete pathways were identified in the LRSP. The top three subpathways included apoptosis. MAPK signaling pathway, and HIF-1 signaling pathway. There were 6 hub IncRNAs, including YLPM1, UBXN8, ERVK13-1, TTTY15, C14orf169, and EPB41L4A-AS1. Subpathways of apoptosis, MAPK signaling pathway, and HIF-1 signaling pathway might play crucial roles in AD after treatment with CsA.

• 出版日期2018-6
• 单位中南大学