An efficient and facile synthesis of inhibitors for hepatitis C viral and anti-SARS agents: 4-aryl-5-cyano-1,6-dihydro-2-thiouracils

作者：Rong Liangce^*; Yin Shan; Xia Sheng; Tao Shimin; Shi Yanhui; Tu Shujiang

来源：Research on Chemical Intermediates, 2012, 38(3-5): 983-994.

DOI：10.1007/s11164-011-0434-4

• Thiouracils
• Three-component reaction
• Heterocyclic compound
• Cycloaddition
• Drug activity

One-pot, multicomponent reaction for the synthesis of 4-aryl-5-cyano-1,6-dihydro-2-thiouracils via three-component from aromatic aldehydes, ethyl 2-cyanoacetate and S-benzylisothiourea hydrochloride (methyl carbamimidothioate sulfate) under methanol is described. These compounds have many drug activities, such as anti-hepatitis C viral, anti-Severe acute respiratory syndrome and anti-HIV-1 integrese activity. The advantages of this procedure include the short reaction time, mild reaction conditions and excellent yields.

• 出版日期2012-3
• 单位江苏师范大学