Autism Symptomatology in Boys with Fragile X Syndrome: A Cross Sectional Developmental Trajectories Comparison with Nonsyndromic Autism Spectrum Disorder

作者：Thurman Angela John; McDuffie Andrea; Kover Sara T; Hagerman Randi J; Abbeduto Leonard

来源：Journal of Autism and Developmental Disorders, 2015, 45(9): 2816-2832.

DOI：10.1007/s10803-015-2443-4

• Fragile X syndrome
• Autism spectrum disorder
• Behavioral phenotype
• Nonverbal cognition
• Expressive vocabulary
• Developmental trajectory

Although males with fragile X syndrome (FXS) are frequently described as demonstrating autism symptomatology, there is much debate regarding whether the behavioral symptoms representing the core domains of autism are the result of the same or different underlying neurological/psychological mechanisms. The present study used a cross-sectional developmental trajectories approach to compare the profiles of autism symptomatology relative to chronological age (CA), nonverbal IQ, and expressive vocabulary ability between individuals with FXS and individuals with nonsyndromic ASD. Results suggest that the onset of autism symptoms and their developmental trajectories in males with FXS differ in important ways as a function of CA, nonverbal cognitive ability, and expressive vocabulary relative to males with nonsyndromic ASD. Theoretical and clinical implications are discussed.

• 出版日期2015-9