Association of visual function and ganglion cell layer thickness in patients with diabetes mellitus type 1 and no or minimal diabetic retinopathy

作者：van Dijk Hille W^*; Verbraak Frank D; Stehouwer Marilette; Kok Pauline H B; Garvin Mona K; Sonka Milan; DeVries J Hans; Schlingemann Reinier O; Abramoff Michael D

来源：Vision Research, 2011, 51(2): 224-228.

DOI：10.1016/j.visres.2010.08.024

• Diabetic retinopathy
• Retina
• Ganglion cell layer
• Diabetic neurodegeneration
• Visual function

Diabetic retinopathy (DR) classically presents with micro-aneurysms, small haemorrhages and/or lipoprotein exudates. Several studies have indicated that neural loss occurs in DR even before vascular damage can be observed. This study evaluated the possible relationship between structure (spectral domain-optical coherence tomography) and Rarebit visual field test) in patients with type 1 diabetes mellitus and no or minimal diabetic retinopathy (DR). Results demonstrated loss of macular visual function and corresponding thinning of the ganglion cell layer (GCL) in the pericentral area of the macula of diabetic patients (Rs = 0.65, p < 0.001). In multivariable logistic regression analysis, GCL thickness remained an independent predictor of decreased visual OR 1.5, 95% CI 1.1-2.1). Early DR seems to include a neurodegenerative component.

• 出版日期2011-1-28