Molecular epidemiology of multidrug-resistant Mycobacterium tuberculosis in Eastern Taiwan

作者：Hsu A H; Lin C B; Lee Y S; Chiang C Y; Chen L K; Tsai Y S; Lee J J^*

来源：International Journal of Tuberculosis and Lung Disease, 2010, 14(7): 924-926.

• multidrug-resistant tuberculosis
• spoligotyping
• transmission
• MIRU-VNTR

Taiwan initiated a multidrug-resistant tuberculosis (MDR-TB) programme in May 2007. Seventy-seven MDR-TB patients were enrolled from May 2007 to February 2009 in Eastern Taiwan. Isolates of 73 (94%) patients were available for genotyping using spoligotyping and MIRU-VNTR (mycobacterial interspersed repetitive unit-variable number of tandem repeats). Spoligotyping results indicated the Beijing strain as the predominant genotype (n = 48,66%). Of the 73 isolates, 28 (38.4%) had a unique pattern and 45 (61.6%) were clustered pattern strains. Epidemiological links could be established in 21 (46.7%) of the 45 patients with a clustered pattern strain. The proportion of MDR-TB patients with a clustered pattern strain in Eastern Taiwan was high.

• 出版日期2010-7
• 单位河北医科大学