Adenovirus DNA Positivity in Nasopharyngeal Aspirate Preceding Hematopoietic Stem Cell Transplantation: A Very Strong Risk Factor for Adenovirus DNAemia in Pediatric Patients

de Pagter Anne P J; Haveman Lianne M; Schuurman Rob; Schutten Martin; Bierings Marc; Boelens Jaap Jan<sup>*</sup>

doi:10.1086/644739

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Adenovirus DNA Positivity in Nasopharyngeal Aspirate Preceding Hematopoietic Stem Cell Transplantation: A Very Strong Risk Factor for Adenovirus DNAemia in Pediatric Patients

作者：de Pagter Anne P J; Haveman Lianne M; Schuurman Rob; Schutten Martin; Bierings Marc; Boelens Jaap Jan^*

来源：Clinical Infectious Diseases, 2009, 49(10): 1536-1539.

DOI：10.1086/644739

摘要

Human adenovirus (HAdV)-positive nasopharyngeal aspirate preceding hematopoietic stem cell transplantation was prospectively analyzed in 62 patients. By multivariate Cox proportional hazard models, HAdV-positive nasopharyngeal aspirate was the only predictor for HAdV DNAemia after hematopoietic stem cell transplantation (P < .001). HAdV DNAemia was a predictor for alloreactive disease. Early detection and intervention might help to prevent HAdV disease after hematopoietic stem cell transplantation.