A Preliminary Study over Second Trimester Biochemical Markers and Their Clinical Utility

作者：Navolan Dan; Vladareanu Simona; Ciohat Ioana; Stoian Dana; Badiu Diana; Craina Marius; Tomovic Miroslav; Birsasteanu Florin^*; Craciunescu Mihaela

来源：Revista de Chimie, 2016, 67(6): 1224-1226.

• second trimester
• biochemical markers
• prediction
• SGA
• PIH

Identification of early markers of pregnancy complications is a goal of materno-fetal medicine. The main purpose of the study was to see if changes in second trimester markers concentration are associated with IUGR and PIH complicated pregnancies. Was analyzed second trimester biochemical markers concentration in seven groups of pregnant women: with birth at term without pregnancy complications (BT) (Group A; n=1628), with SGA without PIH (Group B; n=39), with PIH without SGA (Group C; n=26), with PIH and SGA (Group D; n=6), with PIH or SGA (Group E; n=71), with PIH including SGA (Group F; n=32), and SGA including PIH (Group G; n=45). Second trimester hCG concentration is higher in BT group compared to group E (1.07 +/- 0.01 vs. 0.93 +/- 0.05, p=0.08) and group G (1.07 +/- 0.01 vs. 0.93 +/- 0.04, p=0.05), whereas uE3 concentration is lower in group A compared to group D (0.95 +/- 0.09 vs. 1.28 +/- 0.27; p=0.07), E (0.95 +/- 0.09 vs. 1.01 +/- 0.05; p=0.08) and group G (0.95 +/- 0.09 vs. 1.12 +/- 0.11; p=0.06). Our study showed that hCG value is higher while uE3 is lower in group A compared to group E and group G pregnant women.

• 出版日期2016-6