A prognostic scoring system for adult patients less than 60 years of age with acute lymphoblastic leukemia in first relapse

作者：Advani Anjali^*; Jin Tao; Bolwell Brian; Copelan Edward; Sekeres Mikkael; Sobecks Ronald; Sungren Shawnda; Yurch Melissa; Kalaycio Matt

来源：Leukemia and Lymphoma, 2009, 50(7): 1126-1131.

DOI：10.1080/10428190902962838

• Acute lymphoblastic leukemia
• prognosis
• relapse
• lactate dehydrogenase
• bone marrow transplant

The outcome of patients with acute lymphoblastic leukemia (ALL) in first relapse is poor. We retrospectively evaluated patients with ALL in first relapse, 18-60 years of age, to define a prognostic score. For all patients, a scoring system of 0-3 was developed with 1 point for each of the following: age at diagnosis >= 45 years, lactate dehydrogenase (LDH) at the time of relapse >= 1.5 times upper limits of normal (ULN), not proceeding to allogeneic bone marrow transplant (BMT). A similar scoring system was developed for patients proceeding to BMT. LDH >= 1.5 times ULN at the time of relapse predicted poor overall survival. Patients with a prognostic score of greater than 1 have a poor prognosis, even with BMT, and should be considered for treatment with innovative approaches such as Phase 1 clinical trials.

• 出版日期2009