The VEGF+405 G > C 5 ' untranslated region polymorphism and risk of PCOS: a study in the South Indian Women

作者：Guruvaiah Praveen; Govatati Suresh; Reddy Tumu Venkat; Lomada Dakshayani; Deenadayal Mamata; Shivaji Sisinthy; Bhanoori Manjula^*

来源：Journal of Assisted Reproduction and Genetics, 2014, 31(10): 1383-1389.

DOI：10.1007/s10815-014-0310-4

• PCOS
• VEGF
• SNP
• Haplotype
• South Indian women

The aim of this study was to investigate the association between two common single nucleotide polymorphisms (SNPs) in the vascular endothelial growth factor (VEGF) gene (-460C/T and +405G/C) and polycystic ovary syndrome (PCOS) risk in south Indian women.
This study involves clinically confirmed PCOS patients (n = 126) and non-PCOS controls (n = 130) of south Indian origin (Dravidian linguistic group). Genotyping of the VEGF gene -460C/T and +405G/C SNPs were performed by PCR and sequencing analysis. Haplotype frequencies for multiple loci and the standardized disequilibrium coefficient (D') for pairwise linkage disequilibrium (LD) were assessed by Haploview Software.
The frequencies of +405G/G genotype (P = 0.03) and +405G alleles (P = 0.006) were significantly higher in patients compared to controls. Whereas the genotype and allele frequencies of -460C/T SNP were not significantly different between patients and controls. In addition, LD analysis revealed no significant difference between patients and controls.
Our findings suggest that the VEGF +405G/C polymorphism may constitute an inheritable risk factor for PCOS in south Indian women.

• 出版日期2014-10