A synthetic encapsulating emulsifier using complex-forming pentacosadiynoyl cyclosophoraoses (cyclic beta-(1,2)-D-glucan)

作者：Kim Hwanhee; Dindulkar Someshwar D; Jeong Daham; Park Seyeon; Jun Bong Hyun; Cho Eunae; Jung Seunho

来源：Journal of Industrial and Engineering Chemistry, 2016, 44: 195-203.

DOI：10.1016/j.jiec.2016.08.032

• Cyclosophoraoses
• Emulsifier
• Pentacosadiynyl moiety
• NOESY
• Nanoemulsion

A new pentacosadiynoyl cyclosophoraose (P-Cys) was synthesized using a biosourced cyclooligosac-charide with intrinsic complexation capacity. NOESY analysis revealed that switchable molecular behavior of pentacosadiynoyl moiety attached to P-Cys was dependent on the external lipophilicity. Both encapsulation by cyclosophoraose and switchable emulsification by pentacosadiynoyl moiety in P-Cys make it possible to finely formulate a nanoemulsion state for an external hydrophobic guest molecule like Sudan III. Various physicochemical properties of the emulsions of P-Cys were investigated using TEM and DLS. The results indicate that P-Cys is a useful potential platform for the encapsulating emulsification of bioactive molecules for cosmetic and pharmaceutical applications.

• 出版日期2016-12-25