Health-related quality of life in adult dermatitis patients stratified by filaggrin genotype

作者：Heede Nina G; Thyssen Jacob P; Thuesen Betina H; Linneberg Allan; Szecsi Pal B; Stender Steen; Johansen Jeanne D

来源：Contact Dermatitis, 2017, 76(3): 167-177.

DOI：10.1111/cod.12731

• actinic keratosis
• atopic dermatitis
• epidemiology
• filaggrin mutations
• hand eczema
• health-related quality of life

Background. Information concerning health-related quality of life (HRQoL) and comorbidities of adult dermatitis patients stratified by loss-of-function mutations in the filaggrin gene (FLG) is limited.
Objective. To investigate HRQoL, skin symptoms and comorbidities in adult FLG mutation carriers.
Methods. This cross-sectional study included patients diagnosed with atopic dermatitis and/or hand eczema (n= 520). Patients completed questionnaires about dermatitis, skin symptoms, HRQoL, and comorbidities, including actinic keratosis, and atopic and mental disorders.
Results. FLG mutations (R501X, 2282del4, and R2447X) were identified in 16.9% of patients, and were significantly associated not only with atopic dermatitis, but also independently with skin fissures on the fingers and heels, and self-reported actinic keratosis. Although FLG mutations were significantly associated with reducedHRQoL, as measured by use of the Dermatology Life Quality Index (DLQI), no association with self-reported anxiety or depression was identified. Notably, the highest median DLQI score, reflecting greater impairment, was reported by patients with both FLG mutations and atopic dermatitis. Overall, 19.7% of patients with both atopic dermatitis and FLG mutations reported a 'large or extremely large' impact on their lives; this represents twice the prevalence seen in patients with atopic dermatitis and wild-type FLG (9.6%).
Conclusion. Patients with both atopic dermatitis and common FLG mutations are more frequently affected by reduced HRQoL.

• 出版日期2017-3