Lumbar laminectomy and fusion with routine local application of vancomycin powder: Decreased infection rate in instrumented and non-instrumented cases

作者：Strom Russell G^*; Pacione Donato; Kalhorn Stephen P; Frempong Boadu Anthony K

来源：Clinical Neurology and Neurosurgery, 2013, 115(9): 1766-1769.

DOI：10.1016/j.clineuro.2013.04.005

• Vancomycin powder
• Local antibiotics
• Wound infection
• Lumbar fusion
• Laminectomy
• Spinal instrumentation
• Non-instrumented fusion
• Efficacy

Objective: Wound infections are one of the most common and potentially devastating complications of spinal surgery. Intra-wound application of vancomycin powder has been shown to lower the infection risk following posterior instrumented fusion, but little evidence supports use in other spinal operations. The goal of this study is to assess the efficacy of vancomycin powder for lumbar laminectomy and fusion, both instrumented and non-instrumented. %26lt;br%26gt;Methods: All cases of lumbar laminectomy and posterior fusion (with or without pedicle screw fixation) by a single surgeon were reviewed from 2007 to 2011. Routine application of 1 g vancomycin powder was started in August 2009. Baseline characteristics and operative data were compared between untreated patients and those who received vancomycin powder. Rates of wound infection were compared for all fusions, and then separately for instrumented and non-instrumented cases. %26lt;br%26gt;Results: 253 patients underwent lumbar laminectomy and fusion between 2007 and 2011. Baseline and operative variables were similar between untreated patients (n=97) and those who received vancomycin powder (n=156). Patients were followed for at least one year. The infection rate fell significantly following introduction of vancomycin powder (from 11% to 0%, p = 0.000018). Subgroup analysis revealed significant infection reduction for both instrumented cases (from 12% to 0%, p = 0.000806) and non-instrumented cases (from 10% to 0%, p = 0.0496). No complications attributable to vancomycin powder were identified. %26lt;br%26gt;Conclusion: Local vancomycin powder appears to lower the risk of wound infection following lumbar laminectomy and fusion, both instrumented and non-instrumented. Further studies are needed to optimize dosing of vancomycin powder, assess long-term safety and efficacy, and evaluate use in other spinal operations.

• 出版日期2013-9