Antimicrobial Phenolics and Unusual Glycerides from Helichrysum italicum subsp microphyllum

作者：Taglialatela Scafati Orazio^*; Pollastro Federica; Chianese Giuseppina; Minassi Alberto; Gibbons Simon; Arunotayanun Warunya; Mabebie Blessing; Ballero Mauro; Appendino Giovanni

来源：Journal of Natural Products, 2013, 76(3): 346-353.

DOI：10.1021/np3007149

During a large-scale isolation campaign for the heterodimeric phloroglucinyl pyrone arzanol (1a) from Helichrysum italicum subsp. microphyllum, several new phenolics as well as an unusual class of lipids named santinols (5a-c, 6-8) have been characterized. Santinols are angeloylated glycerides characterized by the presence of branched acyl- or keto-acyl chains and represent a hitherto unreported class of plant lipids. The antibacterial activity of arzanol and of a selection of Helichrysum phenolics that includes coumarates, benzofurans, pyrones, and heterodimeric phloroglucinols was evaluated, showing that only the heterodimers showed potent antibacterial action against multidrug-resistant Staphylococcus aureus isolates. These observations validate the topical use of Helichrysum extracts to prevent wound infections, a practice firmly established in the traditional medicine of the Mediterranean area.

• 出版日期2013-3