Association of a carboxylesterase 1 polymorphism with appetite reduction in children and adolescents with attention-deficit/hyperactivity disorder treated with methylphenidate

作者：Bruxel E M; Salatino Oliveira A; Genro J P; Zeni C P; Polanczyk G V; Chazan R; Rohde L A; Hutz M H^*

来源：The Pharmacogenomics Journal, 2013, 13(5): 476-480.

DOI：10.1038/tpj.2012.25

• adverse reaction
• appetite reduction
• attention deficit hyperactivity disorder
• carboxylesterase 1
• methylphenidate
• pharmacogenetics

Carboxylesterase 1 is the enzyme involved in methylphenidate (MPH) metabolism. The aim of this study was to evaluate the association between a -75 T>G polymorphism and appetite reduction in children with attention-deficit/hyperactivity disorder (ADHD). A sample of 213 children with ADHD was investigated. The primary outcome was appetite reduction measured by the Barkley Stimulant Side Effect Rating Scale applied at baseline, at 1 and 3 months of treatment. MPH doses were augmented until no further clinical improvement or significant adverse events occurred. The G allele presented a trend for association with appetite reduction scores (P = 0.05). A significant interaction between the G allele and treatment over time for appetite reduction scores was also observed (P = 0.03). The G allele carriers presented a higher risk for appetite reduction worsening when compared with T allele homozygotes (odds ratio 3.47, P = 0.01). The present results suggest an influence of carboxylesterase 1 -75 T>G polymorphism on the worsening of appetite reduction with MPH treatment in youths with ADHD.

• 出版日期2013-10