Association of polymorphisms and haplotypes in the 5 ' region of COLIA1 gene with the risk of osteoporotic fractures in Russian women from Volga-Ural region

作者：Selezneva L I^*; Khusainova R I; Nurligayanov R Z; Fazlyeva E A; Usenko K P; Lesnyak O M; Khusnutdinova E K

来源：Russian Journal of Genetics, 2008, 44(2): 180-186.

DOI：10.1134/S1022795408020099

The analysis of -1997GIT, -1663indelT, and +1245G/T polymorphic loci of the 5-region of COLIA1 gene in 124 females aged from 50 to 70 years old with low numbers of traumatic fractures as well as 150 healthy inviduals from Volga-Ural region has been conducted. ne association of -1663indelTand +1245G/T loci with the risk of osteoporotic fractures has been discovered. It has been shown that -1997*G*G/-1663*I*D/+1245*G*T genotype combination and -1997*G/-1663*D/+1245*T haplotype can be considered as markers for fracture development.

• 出版日期2008-2