Multi-institutional validation of a preoperative scoring system which predicts survival for patients with glioblastoma

作者：Chaichana Kaisorn L^*; Pendleton Courtney; Chambless Lola; Camara Quintana Joaquin; Nathan Jay K; Hassam Malani Laila; Li Gordon; Harsh Griffith R; Thompson Reid C; Lim Michael; Quinones Hinojos Alfredo

来源：Journal of Clinical Neuroscience, 2013, 20(10): 1422-1426.

DOI：10.1016/j.jocn.2013.02.007

• Glioblastoma
• Prognosis
• Scoring system
• Surgery
• Survival

Glioblastoma is the most common and aggressive type of primary brain tumor in adults. Average survival is approximately 1 year, but individual survival is heterogeneous. Using a single institutional experience, we have previously identified preoperative factors associated with survival and devised a prognostic scoring system based on these factors. The aims of the present study are to validate these preoperative factors and verify the efficacy of this scoring system using a multi-institutional cohort. Of the 334 patients in this study from three different institutions, the preoperative factors found to be negatively associated with survival in a Cox analysis were age >60 years (p < 0.0001), Karnofsky Performance Scale score <= 80 (p = 0.03), Motor deficit (p = 0.02), language deficit (p = 0.04), and periventricular tumor location (p = 0.04). Patients possessing 0-1, 2, 3, and 4-5 of these variables were assigned a preoperative grade of 1, 2, 3, and 4, respectively. Patients with a preoperative grade of 1, 2, 3, and 4 had a median survival of 17.9, 12.3, 10, and 7.5 months, respectively. Survival of each of these grades was statistically significant (p < 0.05) in log-rank analysis. This grading system, based only on preoperative variables, may provide patients and physicians with prognostic information that may guide medical and surgical therapy before any intervention is pursued.

• 出版日期2013-10