ANTI-SIGNAL RECOGNITION PARTICLE AUTOANTIBODY POSITIVE MYOPATHY

作者：Bodoki Levente^*; Vincze Melinda; Hortobagyi Tibor; Griger Zoltan; Csonka Tamas; Danko Katalin

来源：Ideggyogyaszati Szemle-Clinical Neuroscience, 2014, 67(9-10): 347-353.

• myositis-specific autoantibodies
• signal recognition particle
• necrotizing autoimmune myopathy

The idiopathic inflammatory myopathies are systemic, autoimmune diseases characterized by proximal symmetrical muscle weakness. We review the myositis-associated and myositis-specific autoantibodies, among them the anti-SRP autoantibody. Among those autoimmune myopathy cases, that are associated with autoantibodies, we can detect anti-SRP autoantibody positive myositis cases. We describe the role of signal recognition particle, also its structure and role in protein biosynthesis. We review how the necrotizing autoimmune myopathy is identified, what kind of differences are presented in relationship with the classical polymyositis cases. As we will see the anti-SRP titer correlates with the activity of the disease. We serve some examples from the literature how the disease looks in the childhood and also some rare cases from the literature. At the end of our review we present a case report to draw attention to the importance of the disease.

• 出版日期2014-9-30