科研之友
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摘要
Objectives To determine whether methadone, administered before orthopaedic surgery, results in improved postoperative analgesia compared to buprenorphine. %26lt;br%26gt;Methods Thirty-eight dogs undergoing orthopaedic surgeries (the majority being tibial tuberosity advancement or elbow arthrotomy) were premedicated with 0%26lt;bold%26gt;03%26lt;/bold%26gt;mg/kg acepromazine and either 20 mu g/kg buprenorphine or 0%26lt;bold%26gt;5%26lt;/bold%26gt;mg/kg methadone, intramuscularly, allocated randomly. Anaesthesia was induced with propofol intravenously to effect and maintained with isoflurane in oxygen. 0%26lt;bold%26gt;2%26lt;/bold%26gt;mg/kg meloxicam was administered at anaesthetic induction. Sedation was assessed by means of a dynamic interactive visual analogue and simple descriptive scales and pain by dynamic interactive visual analogue and the short form Glasgow composite pain scales, by a single observer blinded to treatment group at intervals for 8hours following premedication. %26lt;br%26gt;Results Sedation scores were higher than baseline in both groups following premedication until the end of the assessment period (P=0%26lt;bold%26gt;0001%26lt;/bold%26gt;), with no differences between groups. Pain scores were lower overall in dogs premedicated with methadone (dynamic interactive visual analogue scale P=0%26lt;bold%26gt;048%26lt;/bold%26gt;; short form Glasgow composite pain scale P=0%26lt;bold%26gt;0045%26lt;/bold%26gt;), and these dogs required less additional analgesia (42%, compared to 79% premedicated with buprenorphine, P=0%26lt;bold%26gt;045%26lt;/bold%26gt;). %26lt;br%26gt;Clinical Significance At the doses investigated, methadone produced superior analgesia to buprenorphine for 8hours postoperatively in dogs undergoing orthopaedic surgery.
- 出版日期2013-8
