Diminished alveolar microvascular reserves in type 2 diabetes reflect systemic microangiopathy

作者：Chance William W; Rhee Chanhaeng; Yilmaz Cuneyt; Dane D Merrill; Pruneda M Lourdes; Raskin Philip; Hsia Connie C W^*

来源：Diabetes Care, 2008, 31(8): 1596-1601.

DOI：10.2337/dc07-2323

OBJECTIVE - Alveolar microvascular function is moderately impaired in type I diabetes, as manifested by restriction of lung volume and diffusing capacity (DLCO). We examined whether similar impairment develops in type 2 diabetes and defined the physiologic sources of impairment as well as the relationships to glycemia and systemic microangiopathy.
RESEARCH DESIGN AND METHODS - A cross-sectional study was conducted at a university-affiliated diabetes treatment center and outpatient diabetes clinic, involving 69 nonsmoking type 2 diabetic patients without overt cardiopulmonary disease. Lung volume, pulmonary blood flow (Q), DLCO, membrane diffusing capacity (measured from nitric oxide uptake [DLNO]), and pulmonary capillary blood volume (V-C) were determined at rest and exercise for comparison with those in 45 healthy nonsmokers as well as with normal reference values.
RESULTS - In type 2 diabetic patients, peak levels of oxygen uptake, Q and DLCO, DLNO, and V-C at exercise were 10-25% lower compared with those in control subjects. in nonobese patients (BMI <30 kg/m(2)) reductions in DLCO DLNO and V-C were fully explained by the lower lung volume and peak Q, but these factors did not fully explain the impairment in obese patients (BMI >30 kg/m(2)). The slope of the increase in V-C with respect to Q was reduced similar to 20% in patients regardless of BMI, consistent with impaired alveolar-capillary recruitment. Functional impairment was directly related to AIC level, retinopathy, neuropathy, and microalbuminuria in a sex-specific manner.
CONCLUSIONS - Alveolar microvascular reserves are reduced in type 2 diabetes, reflecting restriction of lung volume, alveolar perfusion, and capillary recruitment. This reduction correlates with glycemic control and extrapulmonary microangiopathy and is aggravated by obesity.

• 出版日期2008-8