A novel screening test for colon cancer: Talin-1

作者:Bostanci O; Kemik O*; Kemik A; Battal M; Demir U; Purisa S; Mihmanli M
来源:European Review for Medical and Pharmacological Sciences, 2014, 18(17): 2533-2537.

摘要

OBJECTIVE: Cell adhesion and angiogenesis within the extracellular matrix involve special signaling molecules, such as integrins and the actin binding protein Talin-1. The aim of this study was to investigate and describe the expression of Talin-1 for the early detection of colon cancer. %26lt;br%26gt;PATIENTS AND METHODS: Blood serum samples were collected from 50 healthy volunteers and from 90 patients with colon cancer. Using an enzyme-linked immunosorbent assay (ELISA), all 140 samples were analyzed. %26lt;br%26gt;RESULTS: Preoperative levels of Talin-1 in the serum were significantly higher in patients with colon cancer (p %26lt; 0.001). No significant correlation was found between preoperative levels of Talin-1 in the serum and the age and gender of the patients (p %26lt; 0.05). However, a significant correlation was found between Talin-1 levels and the tumor grade, TNM stage, and lymph node metastasis (p %26lt; 0.001). %26lt;br%26gt;CONCLUSIONS: Talin-1 may play a role in the reinforcement of cell proliferation, cell adhesion, and angiogenesis in colon cancer. Thus, the Talin-1 protein activity may be a novel biomarker to detect colon cancer in humans.

  • 出版日期2014-9