Vitamin D deficiency and insulin resistance in obese African-American adolescents

作者：Nunlee Bland Gail^*; Gambhir Kanwal; Abrams Cynthia; Abdul Mustapha; Vahedi Marjan; Odonkor Wolali

来源：Journal of Pediatric Endocrinology & Metabolism, 2011, 24(1-2): 29-33.

DOI：10.1515/JPEM.2011.107

• African-American
• adiponectin
• adolescents
• insulin resistance
• obesity
• vitamin D

Objective: The study aim determined if low 25-hydroxy vitamin D levels correlated with low levels of adiponectin and insulin resistance in African American adolescents with body mass index >= 85th%.
Patients and methods: Fasting blood levels of adiponectin, 25-hydroxy vitamin D, insulin, glucose, lipid, leptin and glycosylated hemoglobin were measured in a total of 34 (19 study and 15 control) African American adolescents between the ages of 10 and 20 years. Nutritional vitamin D intake and body composition measurements were assessed. Insulin resistance was calculated using the homeostasis model assessment.
Results: Adiponectin, fasting insulin, glucose, leptin, triglycerides, HDL, and 25-hydroxy vitamin D levels all reached statistical significance in the group with body mass index >= 85th percentile when compared to the control population. There was no difference in vitamin D intake between the two groups.
Conclusions: Low vitamin D levels correlated with low adiponectin levels and obesity and insulin resistance.

• 出版日期2011-3