Adenovirus-Vectored Vaccine Provides Postexposure Protection to Ebola Virus-Infected Nonhuman Primates

作者：Wong Gary; Richardson Jason S; Pillet Stephane; Racine Trina; Patel Ami; Soule Geoff; Ennis Jane; Turner Jeffrey; Qiu Xiangguo; Kobinger Gary P^*

来源：Journal of Infectious Diseases, 2015, 212(suppl 2): S379-S383.

DOI：10.1093/infdis/jiv102

• Ebola
• nonhuman primates
• post-exposure
• adenovirus
• vaccine

Ebola virus (EBOV) causes lethal disease in up to 90% of EBOV-infected humans. Among vaccines, only the vesicular stomatitis virus platform has been successful in providing postexposure protection in nonhuman primates. Here, we show that an adjuvanted human adenovirus serotype 5 (Ad5)-vectored vaccine (Ad5-Zaire EBOV glycoprotein) protected 67% (6 of 9) and 25% (1 of 4) of cynomolgus macaques when administered 30 minutes and 24 hours following EBOV challenge, respectively. The treatment also protected 33% of rhesus macaques (1 of 3) when given at 24 hours. The results highlight the utility of adjuvanted Ad5 vaccines for rapid immunization against EBOV

• 出版日期2015-10-1