Association of Cadherin23 Single Nucleotide Polymorphism with Age-Related Hearing Impairment in Han Chinese

作者：Hwang Juen Haur; Liu Kris Sun; Wu Chien Chi; Liu Tien Chen^*

来源：Otolaryngology - Head and Neck Surgery, 2012, 147(3): 531-534.

DOI：10.1177/0194599812446904

• cadherin23
• single nucleotide polymorphism
• age-related hearing impairment
• humans
• Han Chinese

Objective. Genetic variation of cadheri23 (cdh23; 753G>A in exon 7) has been implicated with age-related hearing impairment (ARHI) in mice. This study aimed to test the association of the CDH23 tag single nucleotide polymorphism (SNP) in intron 7 with ARHI in Han Chinese.
Study Design. Individual cohort study.
Setting. Tertiary medical center.
Subjects and Methods. A total of 1175 Han Chinese subjects were divided into the case group (n = 310, 26% with poorest hearing) and the control group (n = 308, the 26% with best hearing) according to the Z(high) score converted from the original frequency-specific hearing thresholds. The CDH23 SNP locus (rs7087735: C/T) in intron 7 (coordinate: 72996763) shown in the HapMap was genotyped with correlation to the hearing phenotype.
Results. The genotype distributions of CDH23 (CC/CT/TT) were not significantly different between the case and control group (P = .489). Compared with genotype CC, the odds ratios of the genotypes CT and TT for ARHI were not significantly different after adjustment for other environmental factors (P = .299 for CT; P = .610 for TT).
Conclusions. Despite that the Ahl allele of Cdh23 had been implicated with ARHI in mice, we found no positive association of the CDH23 tag SNP in intron 7 with ARHI in Han Chinese.

• 出版日期2012-9