A General Protocol for the Synthesis of H-α-Hydroxyphosphinates

作者：Julia, Deschamp; Marc, Lecouvey; Jade, Dussart; Maelle, Monteil; Olivier, Gager; Evelyne, Migianu-Griffoni

来源：Synthesis (Germany), 2019, 51(02): 421-432.

DOI：10.1055/s-0037-1610274

<jats:p>A general synthetic procedure was developed for H-α-hydroxyphosphinates via Abramov reaction. The present work is a complementary study to those reported till now. This methodology has the advantage that it can be applied to various aliphatic and (hetero)aromatic substrates. The H-α-hydroxyphosphinates were easily purified and obtained in good to excellent yields in shorter times. A 31P NMR spectroscopy study has shown that only 2 equivalents of a silylating agent were required.</jats:p>

• 出版日期2019-1
• 单位常州工学院