Discovery of 2-aminobuta-1,3-enynes in asymmetric organocascade catalysis: construction of drug-like spirocyclic cyclohexanes having five to six contiguous stereocenters

作者：Ramachary Dhevalapally B^*; Venkaiah Chintalapudi; Krishna Patoju Murali

来源：Chemical communications, 2012, 48(16): 2252-2254.

DOI：10.1039/c2cc17219d

We present herein for the first time the asymmetric synthesis of drug-like spiranes through reflexive-Michael reaction by using 2-aminobuta-1,3-enyne catalysis under mild conditions.

• 出版日期2012-2-21