Adoption of HPV testing as an adjunct to conventional cytology in cervical cancer screening in Japan

作者：Inoue Masaki^*; Okamura Makoto; Hashimoto Shigeru; Tango Masahiro; Ukita Toshihiko

来源：International Journal of Gynecology & Obstetrics, 2010, 111(2): 110-114.

DOI：10.1016/j.ijgo.2010.06.006

• Cervical cancer screening
• Cytology
• HPV-DNA test
• Japan

Objective: To assess the effectiveness of including HPV testing as an adjunct to conventional cytology in cervical cancer screening. Methods: Atypical epithelial cells (ATC) were classified according to the 2001 Bethesda classification system. The study ran for 6 years from May 2004 to November 2009 in conjunction with public cervical cancer screening for Kanazawa City residents. Patients with ATC (ASC-US, ASC-H, and AGC) underwent parallel testing for high-risk HPV types with the Hybrid Capture II system; HPV positive and cytology-ATC cases were recalled for colposcopic examination and biopsied if necessary. Results were compared with those obtained before HPV screening was initiated. Results: A total of 62 645 women underwent screening over the 6-year period; of these, 3622 (5.8%) were ATC positive, among whom 527 (14.5%) tested HPV-positive. These 527 women (0.8% of the screened population) were recalled for colposcopic examination. The resulting 426 biopsies were diagnosed as CIN 1 (n = 187), CIN 2 (n = 53), CIN 3 (n = 11), and invasive cervical cancer (n = 2). Conclusion: HPV testing as an adjunct to conventional cytology in cervical cancer screening seems to increase detection sensitivity with proven cost-effectiveness.

• 出版日期2010-11