Molecular characterization of chromosomal band 5p15.33: A recurrent breakpoint region in mantle cell lymphoma involving the TERT-CLPTM1L locus

作者：Schilling Georgia^*; Penas Eva Maria Murga; Janjetovic Snjezana; Oliveira Ferrer Leticia; Braig Melanie; Behrmann Petra; Bokemeyer Carsten; Dierlamm Judith

来源：Leukemia Research, 2013, 37(3): 280-286.

DOI：10.1016/j.leukres.2012.10.009

• Mantle cell lymphoma
• Secondary chromosomal aberrations
• 5p15
• TERT
• CLPTM1L

Secondary chromosomal aberrations may contribute to the development of a malignant phenotype in mantle cell lymphoma. Chromosomal band 5p15.33 represents a new recurrent breakpoint in B-cell malignancies.
We present a molecular cytogenetic study of 8 mantle cell lymphoma (MCL) cell lines and 23 patients with MCL to determine and characterize novel secondary aberrations. We detected new secondary recurrent rearrangements in all cell lines and in 7 patients and confirmed 5p15.33 as a recurrent breakpoint in 4 cell lines and one patient. Further molecular characterization by flow-FISH and quantitative RT-PCR suggest TERT and CLPTM1L as target genes of 5p15.33 rearrangements.

• 出版日期2013-3