Measuring the longitudinal relaxation time of GABA in vivo at 3 tesla

作者：Puts Nicolaas A J; Barker Peter B; Edden Richard A E^*

来源：Journal of Magnetic Resonance Imaging, 2013, 37(4): 999-1003.

DOI：10.1002/jmri.23817

• GABA
• MRS
• 3T
• MEGA-PRESS
• T1 relaxation
• macromolecules

Purpose: To measure the in vivo longitudinal relaxation time T1 of GABA at 3 Tesla (T). Materials and Methods: J-difference edited single-voxel MR spectroscopy was used to isolate -aminobutyric acid (GABA) signals. An increased echo time (80 ms) acquisition was used, accommodating the longer, more selective editing pulses required for symmetric editing-based suppression of co-edited macromolecular signal. Acquiring edited GABA measurements at a range of relaxation times in 10 healthy participants, a saturation-recovery equation was used to model the integrated data. Results: The longitudinal relaxation time of GABA was measured as T1,GABA = 1.31 +/- 0.16 s. Conclusion: The method described has been successfully applied to measure the T1 of GABA in vivo at 3T. J. Magn. Reson. Imaging 2013;37:9991003.

• 出版日期2013-4