Herpes simplex virus infection is sensed by both Toll-like receptors and retinoic acid-inducible gene-like receptors, which synergize to induce type I interferon production

作者：Rasmussen Simon B; Jensen Soren B^*; Nielsen Christoffer; Quartin Emanuel; Kato Hiroki; Chen Zhijian J; Silverman Robert H; Akira Shizuo; Paludan Soren R

来源：Journal of General Virology, 2009, 90(1): 74-78.

DOI：10.1099/vir.0.005389-0

The innate antiviral response is initiated by pattern recognition receptors, which recognize viral pathogen-associated molecular patterns. Here we show that retinoic acid-inducible gene (RIG)-I-like receptors (RLRs) in cooperation with Toll-like receptor (TLR) 9 is required for expression of type I interferons (IFNs) after infection with herpes simplex virus (HSV). Our work also identified RNase L as a critical component in IFN induction. Moreover, we found that TLR9 and RLRs activate distinct, as well as overlapping, intracellular signalling pathways. Thus, RLRs are important for recognition of HSV infection, and cooperate with the Toll pathway to induce an antiviral response.

• 出版日期2009-1
• 单位河北医科大学