Nanoplatforms for constructing new approaches to cancer treatment, imaging, and drug delivery: What should be the policy?

作者：Kateb Babak^*; Chiu Katherine; Black Keith L; Yamamoto Vicky; Khalsa Bhavraj; Ljubimova Julia Y; Ding Hui; Patil Rameshwar; Portilla Arias Jose Antonio; Modo Mike; Moore David F; Farahani Keyvan; Okun Michael S; Prakash Neal; Neman Josh; Ahdoot Daniel; Grundfest Warren; Nikzad Shouleh; Heiss John D

来源：NeuroImage, 2011, 54: S106-S124.

DOI：10.1016/j.neuroimage.2010.01.105

• Nanoplatforms
• Nanotechnology
• Image-guided therapy
• Nanomedicine
• Nanoneurosurgery
• Nanostructures
• Contrast agents
• Nanoparticles
• Nanotechnology policy
• Nano-radiology
• Nano-neuroscience
• Nano-neurology

Nanotechnology is the design and assembly of submicroscopic devices called nanoparticles, which are 1-100 nm in diameter. Nanomedicine is the application of nanotechnology for the diagnosis and treatment of human disease. Disease-specific receptors on the surface of cells provide useful targets for nanoparticles. Because nanoparticles can be engineered from components that (1) recognize disease at the cellular level, (2) are visible on imaging studies, and (3) deliver therapeutic compounds, nanotechnology is well suited for the diagnosis and treatment of a variety of diseases. Nanotechnology will enable earlier detection and treatment of diseases that are best treated in their initial stages, such as cancer. Advances in nanotechnology will also spur the discovery of new methods for delivery of therapeutic compounds, including genes and proteins, to diseased tissue. A myriad of nanostructured drugs with effective site-targeting can be developed by combining a diverse selection of targeting, diagnostic, and therapeutic components. Incorporating immune target specificity with nanostructures introduces a new type of treatment modality, nano-immunochemotherapy, for patients with cancer. In this review, we will discuss the development and potential applications of nanoscale platforms in medical diagnosis and treatment. To impact the care of patients with neurological diseases, advances in nanotechnology will require accelerated translation to the fields of brain mapping, CNS imaging, and nanoneurosurgery. Advances in nanoplatform, nano-imaging, and nano-drug delivery will drive the future development of nanomedicine, personalized medicine, and targeted therapy. We believe that the formation of a science, technology, medicine law-healthcare policy (STML) hub/center, which encourages collaboration among universities, medical centers, US government, industry, patient advocacy groups, charitable foundations, and philanthropists, could significantly facilitate such advancements and contribute to the translation of nanotechnology across medical disciplines.

• 出版日期2011-1