Acute effects of indacaterol on lung hyperinflation in moderate COPD: A comparison with tiotropium

作者：Rossi Andrea^*; Centanni Stefano; Cerveri Isa; Gulotta Carlo; Foresi Antonio; Cazzola Mario; Brusasco Vito

来源：Respiratory Medicine, 2012, 106(1): 84-90.

DOI：10.1016/j.rmed.2011.09.006

• Indacaterol
• Tiotropium
• COPD
• Lung hyperinflation

Background: Evidence has been provided that high-dose indacaterol (300 mu g) can reduce lung hyperinflation in moderate-to-severe chronic obstructive pulmonary disease (COPD). %26lt;br%26gt;Aim: To study whether low-dose indacaterol (150 mu g) also reduces lung hyperinflation in comparison with the recommended dose of tiotropium (18 mu g) in moderate COPD. %26lt;br%26gt;Methods: This was a multicenter, randomized, blinded, 3-period cross-over, placebo-controlled study. Spirometry and lung volumes were measured before and 30, 60, 120, 180 and 240 min after the administration of single-doses of indacaterol, tiotropium, or placebo. The primary end-point was the change in peak inspiratory capacity (IC). The area under the 4-h curve (AUC(0-4)) for IC, 1-s forced expiratory volume (FEV(1)) and forced vital capacity (FVC) were secondary variables. %26lt;br%26gt;Results: 49 patients completed the study. On average, peak IC and AUC(0-4) for IC were significantly greater after indacaterol than placebo by 177 mL (p = 0.007) and 142 mL (p = 0.001), respectively. Differences in peak IC and AUC(0-4) for IC between tiotropium and placebo were 120 mL (p = 0.07) and 85 mL (p = 0.052), respectively. Differences between indacaterol and tiotropium were statistically insignificant. Peak IC increased by %26gt;20% in 12 patients with indacaterol and 9 with tiotropium (p = 0.001), and by %26gt;30% in 8 patients with indacaterol and 3 with tiotropium (p = 0.001). The effects of indacaterol and tiotropium on FEV(1) and FVC were statistically significant vs placebo. %26lt;br%26gt;Conclusions: Low-dose indacaterol has a bronchodilator effect that is similar to the recommended dose of tiotropium, but it is slightly superior in reducing lung hyperinflation. Trial registration: ClinicalTrials.gov number: NCT00999908.

• 出版日期2012-1