Divergent Domino Reactions of Sulfur Ylides: Access to Functionalized Six- and Seven-Membered Nitrogen-Heterocycles

作者：Chen, Junlong; Jia, Penghao; Huang, You^*

来源：Organic Letters, 2018, 20(21): 6715-6718.

DOI：10.1021/acs.orglett.8b02810

• DIVERSITY-ORIENTED SYNTHESIS
• VINYL SULFONIUM SALTS
• FUSED HETEROCYCLES
• ALPHA,BETA-UNSATURATED IMINES
• ENANTIOSELECTIVE SYNTHESIS
• STEREOSELECTIVE-SYNTHESIS
• BROMOETHYLSULFONIUM SALT
• CYCLIZATION REACTIONS
• ANNULATION REACTION
• EFFICIENT SYNTHESIS

Divergent domino annulation reactions of sulfur ylides and azadienes were developed. A wide range of functionalized benzofuran-fused six- and seven-membered nitrogen-heterocyclic compounds were prepared in moderate to excellent yields under mild conditions. It is worth noting that the crotonate-derived sulfur ylides could be used as a novel C2 synthon or C3 synthon selectively by simply transforming the base.

• 出版日期2018-11-2
• 单位南开大学