F-18-DOPA PET/CT But Not Ga-68-DOTA-TOC PET/CT Revealed the Underlying Cause of Ectopic Cushing Syndrome

作者：Schalin Jantti Camilla^*; Ahonen Aapo; Seppanen Marko

来源：Clinical Nuclear Medicine, 2012, 37(9): 904-905.

DOI：10.1097/RLU.0b013e318262adc7

• ectopic Cushing syndrome
• LCNEC
• NET
• neuroendocrine carcinoma
• ectopic ACTH
• imaging
• CT
• PET

F-18-DOPAPET/CT but not Ga-68-DOTA-TOC PET/CT revealed the cause of ectopic Cushing syndrome in a 61-year-old man. The patient presented with rapid weight gain, swollen legs, and sleep disturbances. Plasma potassium level was 2.7 mM (reference range, 3.3-4.9 mM), 24-hour urinary cortisol level was 13,124 nmol (reference range, 30-144 nmol), and plasma adrenocorticotropin level was 61 ng/L (reference range, %26lt;48 g/L). CT demonstrated prominent lymph nodes in the left lung hilus and hyperplastic adrenals but no primary tumor. Ga-68-DOTA-TOC PET/CT, which is recommended as the first-line PET imaging, was performed, but it was not diagnostic. Imaging with F-18-DOPA PET/CT revealed the underlying cause.

• 出版日期2012-9