Lysogenic Streptococcus suis Isolate SS2-4 Containing Prophage SMP Showed Increased Mortality in Zebra Fish Compared to the Wild-Type Isolate

作者：Tang, Fang; Zhang, Wei; Lu, Chengping^*

来源：PLos One, 2013, 8(1): e54227.

DOI：10.1371/journal.pone.0054227

• COMPLETE GENOME SEQUENCE
• ESCHERICHIA-COLI
• REPRODUCTIVE FITNESS
• FUNCTIONAL-ANALYSIS
• VIRULENCE
• STRAIN
• PHAGE
• BACTERIOPHAGE
• ENVIRONMENTS
• PNEUMONIAE

Streptococcus suis (S. suis) infection is considered to be a major problem in the swine industry worldwide. Based on the capsular type, 33 serotypes of S. suis have been described, with serotype 2 (SS2) being the most frequently isolated from diseased piglets. Little is known, however, about the pathogenesis and virulence factors of S. suis. Research on bacteriophages highlights a new area in S. suis research. A S. suis serotype 2 bacteriophage, designated SMP, has been previously isolated in our laboratory. Here, we selected a lysogenic isolate in which the SMP phage was integrated into the chromosome of strain SS2-4. Compared to the wild-type isolate, the lysogenic strain showed increased mortality in zebra fish. Moreover the sensitivity of the lysogenic strain to lysozyme was seven times higher than that of the wild-type.

• 出版日期2013-1-10
• 单位南京农业大学