Association between leukaemia and X-ray in children: A nationwide study

作者:Shih Tian Yu; Wu Jay; Muo Chin Shin; Kao Chia Hung*
来源:Journal of Paediatrics and Child Health, 2014, 50(8): 615-618.
DOI:10.1111/jpc.12605

摘要

AimThe frequency of employing radiography is increasing. Long-term risks of performing X-ray procedures on children and adolescents for medical diagnosis have raised significant concerns. %26lt;br%26gt;MethodsIn this study, we adopt the case-control methodology to evaluate the relationship between the incidence rate of acute leukaemia and exposure to radiation during diagnostic X-ray examinations for children. Based on 1998-2010 data obtained from the Taiwan Bureau of National Health Insurance database, we selected 58 children with leukaemia and randomly selected an additional 232 children as the control group. %26lt;br%26gt;ResultsThe mean age of children with leukaemia is 8.92 5.24 years. The risk of leukaemia in children who underwent X-ray examinations increased 2.14-fold (95% CI, 1.18-3.87). In this study, we identified that, when undergoing X-ray examinations, the risk of leukaemia in children increased for both sex and age groups. Specifically, the relationship between leukaemia and X-ray in boys (OR = 3.28, 95%CI, 1.33-8.07) and in ages of 6 to 11 years (OR = 2.58, 95%CI, 1.09-6.10) was significant. Overall, the risk of leukaemia in children who underwent X-ray examinations progressively increased from a ratio of 1.65 to 3.14. Moreover, an identical trend was observed for boys (1.85 to 6.42). %26lt;br%26gt;ConclusionExposure to X-ray increased the risk of leukaemia in children.