Asymmetric synthesis of vicinal amino alcohols via organocatalytic sequential α-amination/Grignard addition reactions of aldehydes

作者：Liu, Can; Weng, Jiang^*; Lin, Zi-Hui; Huang, Wei-Jie; Guo, Jing; Huang, Lin-Jie; Lu, Gui^*

来源：Tetrahedron: Asymmetry , 2017, 28(1): 41-46.

DOI：10.1016/j.tetasy.2016.12.004

• QUATERNARY PHOSPHONIUM SALTS
• DIASTEREOSELECTIVE SYNTHESIS
• 1,3-DICARBONYL COMPOUNDS
• ELECTROPHILIC AMINATION
• KETONES
• DERIVATIVES
• CATALYSIS
• RESOLUTION
• INHIBITOR
• LIGANDS

An organocatalytic sequential alpha-amination/Grignard addition reaction of aliphatic aldehydes is reported. The synthetically useful anti-vicinal amino alcohol derivatives were obtained in high yields and with high stereoselectivities. These derivatives could be easily transformed into oxazolidinones.

• 出版日期2017-1-15
• 单位广州医科大学; 河北医科大学; 中山大学