Association between ALDH2 487G/A polymorphism and hepatocellular carcinoma

作者：Zhou, Dang-Jun^*; Bai, Feng-Jiao

来源：International Journal of Clinical and Experimental Medicine, 2016, 9(2): 3048-3054.

• ALDH2
• hepatocellular carcinoma
• polymorphism
• meta-analysis

Background: Although many studies have investigated the association of ALDH2 487G/A polymorphism with the risk of hepatocellular carcinoma (HCC), their conclusions are controversial. So a meta-analysis was carried out to further determine the correlation between the two sides. Methods: The eligible studies were searched in PubMed, ELSEVIER, and Chinese National Knowledge Infrastructure (CNKI) databases. Finally, 10 studies including 1,495 cases and 2,048 controls were incorporated in this meta-analysis. The pooled odds ratio (OR) with 95% confidence interval (CI) was calculated by the random or fixed effects model to evaluate the association between ALDH2 487G/A polymorphism and risk of HCC. The heterogeneity among studies was analyzed by Q-test and the publication bias was checked with the Begg's funnel plot and Egger's linear regression analysis. Results: The overall result showed that no significant association between ALDH2 487G/A polymorphism and risk of HCC was found under five genetic models including *2*2 vs. *1*1 (OR=1.06, 95% CI=0.80-1.40), *2*2 + *1*2 vs. *1*1 (OR=0.92, 95% CI=0.69-1.23, *2*2 vs. *1*2 + *1*1 (OR=1.22, 95% CI=0.83-1.79), *2 vs. *1 (OR=0.93, 95% CI=0.73-1.19) and *1*2 vs. *1*1 (OR=0.95, 95% CI=0.72-1.24). In subgroup analysis of control source, ALDH2 487G/A polymorphism was also not related to risk of HCC. Conclusion: The study demonstrated ALDH2 487G/A polymorphism may not be a risk factor for HCC. Further well-designed studies with larger sample sizes are needed to verify this result.

• 出版日期2016
• 单位咸阳师范学院