Bile leakage test in liver resection: A systematic review and meta-analysis

作者：Wang Hai Qing; Yang Jian; Yang Jia Yin; Yan Lu Nan^*

来源：World Journal of Gastroenterology, 2013, 19(45): 8420-8426.

DOI：10.3748/wjg.v19.i45.8420

• Bile leakage test
• Bile leakage
• Liver resection
• Postoperative complications
• Meta-analysis

AIM: To assess systematically the safety and efficacy of bile leakage test in liver resection.
METHODS : Randomized controlled trials and controlled clinical trials involving the bile leakage test were included in a systematic literature search. Two authors independently assessed the studies for inclusion and extracted the data. A meta-analysis was conducted to estimate postoperative bile leakage, intraoperative positive bile leakage, and complications. We used either the fixed-effects or random-effects model.
RESULTS: Eight studies involving a total of 1253 patients were included and they all involved the bile leakage test in liver resection. The bile leakage test group was associated with a significant reduction in bile leakage compared with the non-bile leakage test group (RR = 0.39, 95% CI: 0.23-0.67; I-2 = 3%). The white test had superiority for detection of intraoperative bile leakage compared with the saline solution test (RR = 2.38, 95% CI: 1.24- 4.56, P = 0.009). No significant intergroup differences were observed in total number of complications, ileus, liver failure, intraperitoneal hemorrhage, pulmonary disorder, abdominal infection, and wound infection.
CONCLUSION: The bile leakage test reduced postoperative bile leakage and did not increase incidence of complications. Fat emulsion is the best choice of solution for the test.

• 出版日期2013-12-7
• 单位四川大学