Asymmetric Bromine-Lithium Exchange: Application toward the Synthesis of Natural Product

作者：Graff Julien; Debande Thibaut; Praz Jezabel; Guenee Laure; Alexakis Alexandre^*

来源：Organic Letters, 2013, 15(16): 4270-4273.

DOI：10.1021/ol4021157

Asymmetric bromine-lithium exchange has been successfully employed to synthesize bicoumarin chiral building blocks of (+)-isokotanin A and (-)-kotanin in good yields and with an excellent level of enantioselectivity. This is the first reported example of formal syntheses, using this direct methodology, leading to the single (M)-atropoisomer of (+)-isokotanin A and (-)-kotanin building blocks, without any resolution step.

• 出版日期2013-8-16