A comparative study of phytochemical composition of genetically and non-genetically modified soybean (Glycine max L.) and evaluation of antitumor activity

作者：Marrelli Mariangela; Tudisco Raffaella; Mastellone Vincenzo; Conforti Filomena^*

来源：Natural Product Research, 2013, 27(6): 574-578.

DOI：10.1080/14786419.2012.673607

• fatty acids
• colorectal carcinoma
• NO production
• phytosterols
• soybean

Colon cancer is one of the major causes of cancer mortality worldwide. The analysed feeds, containing non-genetically modified (GM) soybean and Roundup Ready soybean, showed a different polyphenolic content and lipophilic composition. Non-GM soybean extract possessed twice the polyphenolic content of GM soybean and the highest number of sterols. Among them, -sitosterol was found to be the major constituent. Methanolic extract of non-GM soybean extract was more potent than GM soybean extract against colon carcinoma cell line LoVo using MTT assay, while the second one showed a slightly higher anti-inflammatory activity. The findings add to epidemiological evidence for the therapeutic effects of soy foods in colorectal carcinoma.

• 出版日期2013-3-1