A one-pot three-component reaction for the preparation of highly functionalized tryptamines

作者：Yeo Se Jeong; Liu Yongxiang; Wang Xiang^*

来源：Tetrahedron, 2012, 68(3): 813-818.

DOI：10.1016/j.tet.2011.11.032

• Tryptamine derivatives
• One-pot process
• Multi-component reaction
• Fischer indole type pathway

We have developed a general one-pot method to provide highly functionalized tryptamine derivatives, via a Fischer indole type pathway. In this article, we demonstrate optimal conditions for a one-pot indole synthesis, allowing for the synthesis of a broad scope of 2-methyl tryptamine derivatives and a precursor for the synthesis of the core structure of some akuammiline alkaloids. Additionally, further modification of the indole products is described. Published by Elsevier Ltd.

• 出版日期2012-1-21