科研之友
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摘要
We report synthesis of a universal allyl linker for solid-phase synthesis, 9-O-(4,4'-Dimethoxytrityl)-10-undecenoic (3), that has a reactive terminal double bond Since allyl cleavage occurs under conditions orthogonal to those used during the solid-phase synthesis and deprotection of DNA or RNA fragments, this linker extends the range of post-synthetic manipulations that can be carried out without cleavage from the support, and means that this linkage could be used to construct affinity columns. Alternatively, it should be possible also to cleave fully protected molecules from the support if so desired.
- 出版日期1996-5-27
- 单位rutgers
