Gold nanoparticles ameliorate acetaminophen induced hepato-renal injury in rats

作者：Reshi Mohd Salim^*; Shrivastava Sadhana; Jaswal Amita; Sinha Neelu; Uthra Chhavi; Shukla Sangeeta^*

来源：Experimental and Toxicologic Pathology, 2017, 69(4): 231-240.

DOI：10.1016/j.etp.2017.01.009

• Acetaminophen
• Gold nanoparticles
• Liver
• Kidney
• Toxicity

Valuable effects of gold particles have been reported and used in complementary medicine for decades. The aim of this study was to evaluate the therapeutic efficacy of gold nanoparticles (AuNPs) against acetaminophen (APAP) induced toxicity. Albino rats were administered APAP at a dose of 2 g/kg p.o. once only. After 24 h of APAP intoxication, animals were treated with three different doses of AuNPs (50 mu g/kg, 100 mu g/kg, 150 mu g/kg) orally or silymarin at a dose of 50 mg/kg p.o., once only. Animals of all the groups were sacrificed after 24 h of last treatment. APAP administered group showed a significant rise in the AST, ALT, SALP, LDH, cholesterol, bilirubin, albumin, urea and creatinine in serum which indicated the hepato-renal damage. A significantly enhanced LPO and a depleted level of GSH were observed in APAP intoxicated rats. Declined activities of SOD and Catalase, after acetaminophen exposure indicated oxidative stress in liver and kidney. The activities of ATPase and glucose-6-Phosphatase were significantly inhibited after APAP administration. AuNPs treatment reversed all variables significantly towards normal level and was found nontoxic. Thus it is concluded that gold nanoparticles played a beneficial role in reducing acetaminophen induced toxicity and can be used in the development of drug against hepatic as well as renal diseases, after further preclinical and clinical studies.

• 出版日期2017-4
• 单位UNESCO