Docking study, synthesis, and in vitro evaluation of fluoro-MADAM derivatives as SERT ligands for PET imaging

作者：Mavel Sylvie^*; Vercouillie Johnny; Garreau Lucette; Raguza Tiziana; Ravna Aina Westrheim; Chalon Sylvie; Guilloteau Denis; Emond Patrick

来源：Bioorganic & Medicinal Chemistry, 2008, 16(19): 9050-9055.

DOI：10.1016/j.bmc.2008.08.002

• SERT
• diphenylsulfide derivatives
• molecular docking

In order to predict affinity of new diphenylsulfides for the serotonin transporter (SERT), a molecular modeling model was used to compare potential binding affinity of new compounds with known potent ligands. The aim of this study is to identify a suitable PET radioligand for imaging the SERT, new derivatives, and their precursors for a C-11 or F-18 radiolabeling, were synthesized. Two fluorinated derivatives displayed good in vitro affinity for the SERT (K(i) = 14.3 +/- 1 and 10.1 +/- 2.7 nM) and good selectivity toward the other monoamine transporters as predicted by the docking study.

• 出版日期2008-10-1
• 单位河北医科大学