A control theoretic approach to malaria immunotherapy with state jumps

作者：Chang H^*; Astolfi A; Shim H

来源：Automatica, 2011, 47(6): 1271-1277.

DOI：10.1016/j.automatica.2011.03.009

• Malaria
• Immunotherapy
• Hybrid systems
• State jump
• Impulsive control

We investigate a control method for malaria dynamics to boost the immune response using a model-based approach. The idea of state jump is introduced and discussed using a hybrid model. To implement the state jumps we use a physiologically feasible method for the biological system, whereby the introduction of a pathogen into the system steers it to a desirable status. It is noted that we take advantage of a pathogen to implement state jumps in the system. The study is supported by recently reported experimental results.

• 出版日期2011-6