NEW SUBSTITUTED PYRROLES OBTAINED IN SEARCHING FOR PYRROLO[1,2-a]QUINAZOLINE FRAMEWORK

作者：Dumitrescu Denisa; Popa Marcel Mirel^*; Georgescu Florentina; Georgescu Emilian; Barbu Loredana; Dumitrascu Florea

来源：Romanian Journal of Chemistry, 2013, 58(9-10): 785-+.

• N-atylpyrroles
• one-pot synthesis
• heterocycles
• pyrrolo[1,2-a]quinazoline
• N-ylides

The synthesis of new highly substituted N-arylpyrroles was achieved by 1,3-dipolar cycloaddition of the quinazolinium N-ylides with acetylenic dipolarophiles. The reaction was conducted as one-pot procedure in 1,2-epoxybutane as reaction medium and proton scavenger. Structural variety of compounds was conferred by the use of various symmetrical and non-symmetrical acetylenic dipolarophiles. In the case of symmetrical dipolarophiles (i.e. Dimethyl acetylenedicarboxylate) the pyrrolo[1,2-a]quinazoline framework could be isolated and characterized.

• 出版日期2013-10