Anti-inflammatory effects and structure elucidation of two new compounds from Astragalus membranaceus (Fisch) Bge. var. mongholicus (Bge) Hsiao

作者：Wang Qing-Hu^*; Han Na-Ren-Chao-Ke-Tu; Dai Na-Yin-Tai; Wang Xiu-Lan; Ao Wu-Li-Ji

来源：Journal of Molecular Structure, 2014, 1074: 284-288.

DOI：10.1016/j.molstruc.2014.06.020

• Astragalus membranaceus (Fisch) Bge. var. mongholicus (Bge) Hsiao
• 1-hydroxy-5-methylolbenzol-2-O-beta-D-glucoside
• (3R, 4R)-4,7-hydroxy-2 ',3 '-dimethoxyisoflavane-4 '-O-beta-D-glucoside
• Spectroscopic methods
• Anti-inflammatory

Phytochemical study of the ethanol extract of Astragalus membranaceus (Fisch) Bge. var. mongholicus (Bge) Hsiao resulted to the isolation of two new compounds, 1-hydroxy-5-methylolbenzol-2-O-beta-D-glucoside (1) and (3R, 4R)-4,7-hydroxy-2',3'-dimethoxyisoflavane-4'-O-beta-D-glucoside (2). The structure of the isolated compounds were elucidated on the basis of the spectroscopic methods including UV, IR, ESI-MS, 1D NMR and 2D NMR techniques, and by comparison with those reported in the literature. The new compounds were investigated for its effect against inflammation induced by egg-albumin and carrageenan in rats.

• 出版日期2014-9-25
• 单位内蒙古民族大学