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摘要
Obesity and visceral fat accumulation increase the risk for the development of type 2 diabetes, dyslipidemia, and cardiovascular disease. Dissection of the molecular mechanisms underlying obesity and its relationship to insulin resistance and the metabolic syndrome are essential for developing new strategies for prevention and treatment of these disorders. However, the mechanistic link between obesity and associated metabolic and vascular diseases is not entirely clear. In the last two decades, advances in obesity research have led to the recognition that adipose tissue is an active endocrine organ secreting multiple bioactive factors termed adipokines. Alterations in circulating adipokines, including leptin, adiponectin, interleukin-6, retinol binding protein 4, vaspin, adipocyte fatty acid binding protein, fibroblast growth factor 21, and many others, are frequently associated with metabolic and cardiovascular complications of obesity. Therefore, changes in adipokine secretion may provide a link between adipose tissue accumulation and the metabolic function of other tissues, such as liver and skeletal muscle. Dysregulation of adipokines is emerging as an important mechanism by which adipose tissue contributes to systemic insulin resistance and metabolic disease.
- 出版日期2009-2
