AKAP10 (I646V) functional polymorphism predicts heart rate and heart rate variability in apparently healthy, middle-aged European-Americans

作者：Neumann Serina A^*; Tingley Whittemore G; Conklin Bruce R; Shrader Catherine J; Peet Eloise; Muldoon Matthew F; Jennings J Richard; Ferrell Robert E; Manuck Stephen B

来源：Psychophysiology, 2009, 46(3): 466-472.

DOI：10.1111/j.1469-8986.2009.00802.x

• AKAP10
• Heart rate variability
• A kinase-anchoring protein 2
• Autonomic function

Previous evidence suggests that the dual-specific A kinase-anchoring protein 2 functional polymorphism (AKAP10 (A/G) I646V) influences heart rate (HR) and heart rate variability (HRV) in mice and humans (N=122) with cardiovascular disease. Here, we asked whether this AKAP10 variant predicts HR and HRV in a large sample of healthy humans. Resting HR and short-term time and frequency domain measures of HRV (5 min during paced and unpaced respiration conditions) were assessed in a U.S. community sample (N=1,033) of generally healthy men and women (age 30-54) of European ancestry. Each person was genotyped for the AKAP10 variant. As with previous work, the AKAP10 Val allele predicted greater resting HR (Paced p <.01; Unpaced p <.03) and diminished HRV (Paced ps <.05) suggesting that this variant may modulate the sensitivity of cardiac pacemaker cells to autonomic inputs, possibly conferring risk for arrhythmias and sudden cardiac death.

• 出版日期2009-5